Mission Valley Cannabis from

Cannabis 21 Plus Dispensary

A visit to Mission Valley at any time of the year is ideal for the history buff, adventurous spirit or anyone seeking a variety of activities, gorgeous views and the opportunity to kick back and relax. About six miles from Mission Beach, there’s no shortage of things to eat, experience and enjoy. Take a seat on an open air patio, order a freshly made tortilla, and people-watch. Tour the Mission San Diego de Alcala, ghost-hunt at the Whaley House, indoor skydive or rock climb at Mission Trails Regional Park.

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Along with over 200 shops and all sorts of restaurants

Mission Valley is home to California’s premier recreational marijuana dispensary. Cannabis 21 Plus Dispensary opens our doors to our loyal locals, tourists, those just trying out cannabis for the first time, and aficionados with high expectations. Our friendly and knowledgeable budtenders are here to answer questions and match your preferences to the perfect product.

Find the Cannabis You’re Looking For

Cannabis 21 Plus Dispensary offers that ideal combination of extensive quantity with amazing quality. Our shelves overflow with the brands you’ve heard good things about. Discover innovative strains and new favorites. Browse carefully curated flower, pre-rolls, vapes, carts, concentrates, topicals, edibles, CBD pet products, clones and seeds, merchandise and so much more. We cater to your lifestyle with a variety of potency, online ordering, in-store pickup, and delivery.

(619) 906-5546

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The best way to save money on premium cannabis is to subscribe to our loyalty program and rewards. Cannabis 21+ has unbelievable prices and promotional deals on a staggering variety of products offered both online and at our multiple dispensary locations.

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Mission Valley, CA

North Park, CA

Hillcrest, CA

San Diego, CA

Normal Heights, CA

University Heights, CA